Dementia Disease In AD A Case Study - 1039 Words

And Tau is the only cause for dementia but in AD there is no correlation between amyloid plaques alone and the decline of cognition as Tau is the main component of toxicity that cause the dementia disease in AD. Structural and functional neuroimaging such as MRI is a sensitive and accurate tool to differential diagnosis between AD and FTD phenotypes as In AD there id brain weight and volume reduction in specific brain regions than others such as hippocampus and entorhinal cortex and a distinctive atrophy in both anterior temporal lobes and frontal lobes and also a decrease in the thickness of cortex to predict the MCI to AD conversion as it is useful in diagnosis at earlier stage (Piguet et al., 2011). In bvFTD there are pathological†¦show more content†¦People with down syndrome have more risk of developing dementia at early age (Menà ©ndez, 2005) Genetic Risk factors. The genetic risk factors in AD is about 5% of patients which caused by autosomal dominant mutations in these three genes presenilin 1, presenilin 2 and amyloid precursor protein (APP) which are responsible for developing AD, also the presence of the apolipoprotein E (APOE) apoE4 allele as it identified in the development of both the early- and late-onset forms of AD and contribute to 15-20% of AD (Qiu et al., 2004). There are 3 genes are associated with developing frontotemporal dementia FTD MAPT, GRN and C9ORF72 but most of cases are sporadic and 5-10 % are caused by only one of the theses genes (Bertram Tanzi, 2005). : management or intervention strategies currently available for There are pharmacological and nonpharmacological intervention strategies for AD and FTD. The current pharmacological interventions are providing the symptomatic treatment of the disease with variable efficacy degree but does not modify the disease progression process(Kumar Singh, 2015). 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